Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
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چکیده
منابع مشابه
Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
Type 2 diabetes mellitus (T2DM) is a pervasive metabolic syndrome that is characterized by insulin resistance, hyperglycemia and dyslipidemia. As full agonists of PPARγ, thiazolidinedione (TZD) drugs elicit antidiabetic effects by targeting PPARγ but is accompanied by weight gain, fluid retention and cardiovascular risk associated with their transcriptional agonism potency. We here identify a n...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep12222